| 1 | TRAVERE THERAPEUTICS INC USD 0.0001TVTX | 5,52% |
| 2 | XENCOR INC USD 0.01XNCR | 5,42% |
| 3 | HALOZYME THERAPEUTICS INC USD 0.001HALO | 3,76% |
| 4 | XERIS BIOPHARMA HLDGS IN USD 0.0001XERS | 3,38% |
| 5 | ARGENX SE EUR 0.1 ADRARGX | 3,33% |
| 6 | LIGAND PHARMACEUTICALS IN USD 0.001LGND | 3,28% |
| 7 | ROYALTY PHARMA PLC USD 0.0001RPRX | 3,25% |
| 8 | ZEVRA THERAPEUTICS INC USD 0.0001ZVRA | 3,18% |
| 9 | JAZZ PHARMACEUTICALS PLC USD 0.0001JAZZ | 3,12% |
| 10 | SAREPTA THERAPEUTICS INC USD 0.0001SRPT | 3,1% |
| 11 | INCYTE CORP USD 0.001INCY | 3,04% |
| 12 | INNOCARE PHARMA L USD 0.000002 144A9969.HK | 2,99% |
| 13 | GENMAB AS DKK1GMAB.CO | 2,91% |
| 14 | AGIOS PHARMACEUTICALS INC USD 0.001AGIO | 2,78% |
| 15 | VERTEX PHARMACEUTICALS INC USD 0.01VRTX | 2,75% |
| 16 | BASILEA PHARMACEUTICA AG AL CHF 1.0BSLN.SW | 2,73% |
| 17 | BEONE MEDICINES LTD USD 0.0001 ADRONC | 2,72% |
| 18 | BIOCRYST PHARMACEUTICALS I USD 0.01BCRX | 2,71% |
| 19 | MIRUM PHARMACEUTICALS IN USD 0.0001MIRM | 2,69% |
| 20 | SWEDISH ORPHAN BIOVITRUM A SEK 0.55SOBI.ST | 2,68% |
| 21 | BRIDGEBIO PHARMA INC USD 0.001BBIO | 2,64% |
| 22 | ARBUTUS BIOPHARMA CORP NPVABUS | 2,62% |
| 23 | PTC THERAPEUTICS INC USD 0.001PTCT | 2,55% |
| 24 | BIOMARIN PHARMACEUTICAL I USD 0.001BMRN | 2,51% |
| 25 | KYOWA KIRIN CO LTD NPV4151.T | 2,48% |
| 26 | PHARMA MAR SA EUR 0.6PHM.MC | 2,4% |
| 27 | IPSEN SA EUR 1.0IPN.PA | 2,37% |
| 28 | UNITED THERAPEUTICS CORP D USD 0.01UTHR | 2,33% |
| 29 | EISAI CO LTD NPV4523.T | 2,25% |
| 30 | LG CHEMICA KRW5000051910.KS | 2,18% |
| 31 | ALNYLAM PHARMACEUTICALS IN USD 0.01ALNY | 1,92% |
| 32 | IONIS PHARMACEUTICALS INC USD 0.001IONS | 1,8% |
| 33 | PHARMING GROUP NV EUR 0.01PHARM.AS | 1,68% |
| 34 | ULTRAGENYX PHARMACEUTICAL USD 0.001RARE | 1,66% |
| 35 | CHUGAI PHARMACEUTICAL CO LTD NPV4519.T | 1,64% |
| 36 | NIPPON SHINYAKU CO LTD NPV4516.T | 1,64% |
